The Vikings (1-1) are set to host the Buccaneers (1-0) at noon (CT) Sunday.
The Week 3 lineup of games includes a couple of eyebrow-raising interconference matchups, as well as a face-off between the undefeated Falcons and Lions.
The Atlanta-at-Detroit game is in the same time slot as Minnesota's contest with Tampa Bay, but it is worth keeping track of during breaks in the Vikings game.
Here are some notes on that game, as well as Seattle's trip to Tennessee and Oakland's cross-country trek to Washington.
Atlanta Falcons (2-0) at Detroit Lions (2-0) Noon (CT) Sunday | Ford Field
Falcons QB Matt Ryan has 507 passing yards and six touchdowns against one interception for a passer rating of 128.3 in two previous matchups with the Lions.
Atlanta RB Devonta Freeman leads the NFL in yards from scrimmage since 2015 with 3,314. He had 100 scrimmage yards and two scores last week against Green Bay.
WR Julio Jones has the most receiving yards (3,454) and second-most catches (228) since 2015.
CB Desmond Trufant recorded an interception and a 15-yard fumble return for a touchdown last week, and former Gopher, LB De'Vondre Campbell, recorded his first career sack when he took down Aaron Rodgers.
Lions QB Matthew Stafford has averaged 276.6 passing yards and totaled 32 touchdowns against six interceptions for a combined passer rating of 105.7 in his past 15 home games.
Detroit's Theo Riddick has more receptions (142) than any other NFL running back since 2015. Nine of those catches have been for touchdowns.
WR Golden Tate has caught six or more passes in each of his past three home games.
Lions DE Ezekiel Ansah had 3.0 sacks and forced a fumble against the New York Giants, pushing his career total to 35 in 61 games.
Jamal Agnew returned a punt 88 yards for a touchdown against the Giants on Monday Night Football.
Seattle Seahawks (1-1) at Tennessee Titans (1-1) | 3:05 p.m. (CT) Sunday | Nissan Stadium
Seahawks QB Russell Wilson has been impressive against AFC competition, averaging 297.6 yards per game and totaling 22 touchdowns against one interception for a rating of 127.9 in his past seven games.
Rookie RB Chris Carson led Seattle with 93 rushing yards in Week 2, when the Seahawks beat the 49ers 12-9.
Jimmy Graham has more receiving yards (5,933) and the second-most touchdown receptions (54) of any tight end since 2011.
Seahawks LB Bobby Wagner is one of three defenders with 500-plus tackles (520), 10-plus sacks (12) and four or more interceptions since 2013. He recorded his fourth in that span last week against San Francisco.
Titans QB Marcus Mariota has also been effective in interconference games, throwing 18 touchdowns against three interceptions and totaling a passer rating of 121.4 in seven games against the NFC.
RB DeMarco Murray has 6,584 career rushing yards (since 2011); backfield mate Derrick Henry rushed for a career-best 92 yards last week at Jacksonville.
TE Delanie Walker has combined for 257 yards and three scores in his past three games against NFC foes.
LB Wesley Woodyard is one of four players with 15-plus sacks (17.5) and seven or more (seven) interceptions since 2012.
Oakland Raiders (2-0) at Washington Redskins (1-1) | 7:30 p.m. (CT) Sunday | FedExField
Derek Carr will make his 50th career start for the Raiders. If he throws four touchdown passes, he can become the fourth in NFL history to pass for 90 touchdowns in his first 50 starts.
RB Marshawn Lynch has 75 rushing touchdowns, which is second-most in the NFL since 2007 behind former Viking Adrian Peterson.
WR Amari Cooper has 523 yards and three touchdowns in his past five games against NFC foes.
Safety Reggie Nelson has 35 interceptions since 2007, which is second-most in that span.
Redskins QB Kirk Cousins has totaled 1,549 yards and 10 touchdowns against five interceptions in his past five games against AFC teams.
Washington's Jordan Reed leads all tight ends with 17 touchdown catches since 2015.
LB Ryan Kerrigan has 8.5 sacks, two forced fumbles and an interception in his past 11 home games and is the only linebacker with 40-plus sacks (44) and 14 forced fumbles since 2013.