| DATE | OPPONENT (ATTENDANCE) | RESULT | HEAD COACH | STARTING QB |
| 9/17/1961 | vs. Chicago (32,236) | W, 37-13 | Norm Van Brocklin | George Shaw |
| 9/16/1962 | at Green Bay (38,669) | L, 7-34 | Norm Van Brocklin | Fran Tarkenton |
| 9/15/1963 | at San Francisco (30,781) | W, 24-20 | Norm Van Brocklin | Fran Tarkenton |
| 9/13/1964 | vs. Baltimore Colts (35,563) | W, 34-24 | Norm Van Brocklin | Fran Tarkenton |
| 9/19/1965 | at Baltimore Colts (56,562) | L, 16-35 | Norm Van Brocklin | Fran Tarkenton |
| 9/11/1966 | at San Francisco (29,312) | T, 20-20 | Norm Van Brocklin | Fran Tarkenton |
| 9/17/1967 | vs. San Francisco (39,638) | L, 21-27 | Bud Grant | Ron VanderKelen |
| 9/14/1968 | vs. Atlanta (45,563) | W, 47-7 | Bud Grant | Joe Kapp |
| 9/21/1969 | at NY Giants (62,900) | L, 23-24 | Bud Grant | Gary Cuozzo |
| 9/20/1970 | vs. Kansas City (47,900) | W, 27-10 | Bud Grant | Gary Cuozzo |
| 9/20/1971 | at Detroit (54,418) | W, 16-13 | Bud Grant | Gary Cuozzo |
| 9/18/1972 | vs. Washington (47,900) | L, 21-24 | Bud Grant | Fran Tarkenton |
| 9/16/1973 | vs. Oakland (46,619) | W, 24-16 | Bud Grant | Fran Tarkenton |
| 9/15/1974 | at Green Bay (56,312) | W, 32-17 | Bud Grant | Fran Tarkenton |
| 9/21/1975 | vs. San Francisco (48,418) | W, 27-17 | Bud Grant | Fran Tarkenton |
| 9/12/1976 | at New Orleans (58,156) | W, 40-9 | Bud Grant | Fran Tarkenton |
| 9/18/1977 | vs. Dallas (47,678) | L, 10-16 (OT) | Bud Grant | Fran Tarkenton |
| 9/3/1978 | at New Orleans (54,187) | L, 24-31 | Bud Grant | Fran Tarkenton |
| 9/2/1979 | vs. San Francisco (46,539) | W, 28-22 | Bud Grant | Tommy Kramer |
| 9/7/1980 | vs. Atlanta (44,733) | W, 24-23 | Bud Grant | Tommy Kramer |
| 9/5/1981 | at Tampa Bay (66,287) | L, 13-21 | Bud Grant | Steve Dils |
| 9/12/1982 | vs. Tampa Bay (58,440) | W, 17-10 | Bud Grant | Tommy Kramer |
| 9/4/1983 | at Cleveland (70,087) | W, 27-21 | Bud Grant | Tommy Kramer |
| 9/2/1984 | vs. San Diego (57,276) | L, 13-42 | Les Steckel | Tommy Kramer |
| 9/8/1985 | vs. San Francisco (57,375) | W, 28-21 | Bud Grant | Tommy Kramer |
| 9/7/1986 | vs. Detroit (54,851) | L, 10-13 | Jerry Burns | Tommy Kramer |
| 9/13/1987 | vs. Detroit (57,061) | W, 34-19 | Jerry Burns | Wade Wilson |
| 9/4/1988 | at Buffalo (76,783) | L, 10-13 | Jerry Burns | Wade Wilson |
| 9/10/1989 | vs. Houston (54,015) | W, 38-7 | Jerry Burns | Wade Wilson |
| 9/9/1990 | at Kansas City (68,363) | L, 21-24 | Jerry Burns | Wade Wilson |
| 9/1/1991 | at Chicago (64,112) | L, 6-10 | Jerry Burns | Wade Wilson |
| 9/6/1992 | at Green Bay (58,617) | W, 23-20 (OT) | Dennis Green | Rich Gannon |
| 9/5/1993 | at LA Raiders (44,120) | L, 7-24 | Dennis Green | Jim McMahon |
| 9/4/1994 | at Green Bay (59,487) | L, 10-16 | Dennis Green | Warren Moon |
| 9/3/1995 | at Chicago (63,036) | L, 14-31 | Dennis Green | Warren Moon |
| 9/1/1996 | vs. Detroit (52,972) | W, 17-13 | Dennis Green | Warren Moon |
| 8/31/1997 | at Buffalo (79,139) | W, 34-13 | Dennis Green | Brad Johnson |
| 9/6/1998 | vs. Tampa Bay (62,538) | W, 31-7 | Dennis Green | Brad Johnson |
| 9/12/1999 | at Atlanta (69,555) | W, 17-14 | Dennis Green | Randall Cunningham |
| 9/3/2000 | vs. Chicago (64,104) | W, 30-27 | Dennis Green | Daunte Culpepper |
| 9/9/2001 | vs. Carolina (64,108) | L, 13-24 | Dennis Green | Daunte Culpepper |
| 9/8/2002 | at Chicago (63,226) * | L, 23-27 | Mike Tice | Daunte Culpepper |
| 9/7/2003 | at Green Bay (70,505) | W, 30-25 | Mike Tice | Daunte Culpepper |
| 9/12/2004 | vs. Dallas (64,105) | W, 35-17 | Mike Tice | Daunte Culpepper |
| 9/11/2005 | vs. Tampa Bay (63,939) | L, 13-24 | Mike Tice | Daunte Culpepper |
| 9/11/2006 | at Washington (90,608) | W, 19-16 | Brad Childress | Brad Johnson |
| 9/9/2007 | vs. Atlanta (62,815) | W, 24-3 | Brad Childress | Tarvaris Jackson |
| 9/8/2008 | at Green Bay (71,004) | L, 19-24 | Brad Childress | Tarvaris Jackson |